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CLINICAL SIGNIFICANCE OF IMMUNOPHENOTYPE AND CROSS-LINEAGE EXPRESSION OF ACUTE LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1009-9921.2003.05.003
- Key Word:
- 白血病;急性;免疫分型;交叉表达
Abstract： 目的:研究急性白血病(AL)免疫分型及其特殊表型--交叉表达的特征及临床意义.方法:选用16种单克隆抗体,应用直接及间接免疫荧光标记方法,对128例急性白血病患者进行免疫分型.结果:按免疫表型的特征可将其分为3类:系列专一性表达;交叉表达;"裸细胞"型.以系列专一性比例最高,在ANLL和ALL中分别占73.3%和78.9%;"裸细胞"型最低,在ANLL和ALL中分别占6.7%和5.3%;交叉表达在ANLL和ALL中分别占20.0%和15.8%.且交叉表达的病例中,CD+7ANLL以及伴有B系抗原表达的ANLL患者CR率均低于系列专一性表达者,p170表达率较高.结论:急性白血病免疫分型可出现系列专一性表达、交叉表达、"裸细胞"型3种类型;交叉表达的患者可伴有p170高表达,完全缓解率低于系列专一性表达者.
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