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GM-CSF RECEPTOR α SUBUNIT EXPRESSION IN ACUTE LEUKEMIA CASES
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2003.02.002
- Key Word:
- 粒细胞-巨噬细胞集落刺激因子受体α;急性白血病;临床意义
Abstract： 目的:探讨GM-CSF受体α亚单位表达在急性白血病中的意义.方法:采用流式细胞技术检测47例初诊急性白血病患者GM-CSF受体α亚单位表达,同时采用生化法测定血清LDH和HBDH,并于标准化疗第1疗程结束时计算MBDI.结果:AML患者GM-CSF受体α亚单位表达明显高于ALL患者;GM-CSF受体α亚单位的较高表达主要见于AML-M5和AML-M0患者,ALL患者呈阴性表达;GM-CSF受体α亚单位的表达水平在血清LDH/HBDH升高组与正常组两组间、在MB-DI≥50%与＜50%两组间无显著性差异.结论:急性白血病GM-CSF受体α亚单位表达测定对于AML尤其是AML-M5和AML-M0的诊断与鉴别诊断有帮助;GM-CSF受体α亚单位表达水平似乎与白血病细胞肿瘤负荷和化疗近期疗效无关.
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