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THE RELATIONSHIP BETWEEN APOPTOSIS OF LEUKEMIC CELLS INDUCED BY CHEMOTHERAPEUTIC DRUGS IN VITRO AND CLINICAL RESPONSE
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2003.01.002
- Key Word:
- 白血病;淋巴细胞;急性;凋亡;化疗
Abstract： 目的:探索急性淋巴细胞白血病(ALL)患者体外化疗药物诱导白血病细胞凋亡在化疗疗效预测中的价值.方法:应用TdT介导的脱氧核苷酸切口和末端标记法(Tunel)、单克隆抗体免疫组化检测等方法研究28例初治ALL患者体外化疗药物诱导白血病细胞凋亡、bcl-2表达与临床化疗疗效的关系.结果:28例ALL患者中,20例获完全缓解(CR)者.bcl-2表达显著低于8例未缓解(NR)者(P＜0.05);CR患者长春新碱(VCR)、柔红霉素(DNR)和地塞米松(DXM)体外诱导白血病细胞凋亡率均高于NR患者,差异有显著性(P均＜0.05);体外VCR、DNR和DXM 3种药诱导白血病细胞的总凋亡率,可以作为临床预测ALL患者VDCP方案疗效的定量指标.结论:体外化疗药物能否有效地诱导白血病细胞凋亡是判断ALL患者化疗敏感性的重要指标.
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