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CLINICAL SIGNIFICANCE OF CD34 EXPRESSION IN ACUTE PROMYETOCYLIC LEUKEMIA

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
6
DOI:
10.3760/cma.j.issn.1009-9921.2002.06.007
Key Word:
急性早幼粒细胞白血病;CD(34)表达;临床意义

Abstract: 目的:探讨CD34表达在急性早幼粒细胞白血病(APL)的临床意义。方法:用RT-PCR检测PML-RARα融合基因和其异构型。用流式细胞术检测CD34)、CD13、CD33、CD14、HLA-DR的表达。结果:50例APL,17例CD34+,33例CD34-。17例CD34+APL中14例(82%)为M(3b)(M(3V)),而CD34-APL33例中7例为M(3b)。CD34+APL15例(88%)CR,颅内出血死亡2例,早期复发4例(26%)。CD34-APL28例(85%)CR,颅内出血死亡2例,早期复发1例。就诊时,CD34-APL外周血白细胞数明显高于CD34)-者分别为(56.7±15.1)×109/L和(3.6±1.4)×109/L。14例CD34+M(3b)其PML-RARα为短型11例,长型3例;而9例CD34-M(3a)为长型7例,短型2例。结论:CD34+APL其特征有:M(3b)形态多,白细胞数常增高,PML-RARα短型多,ATRA治疗敏感和易早期复发。对CD34)+APL加强缓解后治疗有助于减少早期复发。

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