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The Relationship Between Expression of p170 or MRP and Prognosis in Newly Diagnosed Acute Leukemia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2002.01.003
- Key Word:
- 白血病;急性;多药耐药;预后
Abstract： 目的：探讨多药耐药蛋白(p170)和多药耐药相关蛋白(MRP)表达与初治急性白血病(AL)患者化疗效果的关系。方法：用流式细胞仪检测29例初治AL患者骨髓单个核细胞中p170和MRP蛋白表达。结果：初治AL患者p170和MRP蛋白表达率分别为37.9％和41.4％；MRP蛋白阳性与阴性患者的首次完全缓解(CR)差异无显著性(P＞0.05)；而p170蛋白阳性与阴性患者的首次完全缓解(CR)有显著性差异(P ＜0.05)；p170和MRP蛋白两者之间无相关性。结论：作为预测初治AL患者化疗效果的敏感性指标，p170明显优于MRP蛋白。
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