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PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA AN ANALYSIS OF 21 CASES
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.06.007
- Key Word:
- Ph染色体;急性,淋巴细胞,白血病;大剂量Ara-C;环磷酰胺;足叶乙甙
Abstract： 目的:分析Ph阳性急淋的细胞遗传学、临床疗效及预后,并对比成人和儿童患者的临床特点.方法:总结21例初治Ph阳性急淋患者的CR率,以及不同巩固方案的疗效,同时对白血病细胞的生物学特征进行研究.结果:儿童与成人患者在疗效以及预后方面无显著性差异(P＜0.05);本组患者CR率为76%;在各种不同巩固方案中,大剂量Ara-C DFS为(10.944±1.774)月,中位生存时间19月,未用大剂量Ara-C DFS为(2.840±0.955)月,中位生存时间8月,P值分别为0.003、0.182;CTX/VP16使用者DFS为(7.667±1.858)月,中位生存时间19月,未用CTX/VP16DFS为(2.753±1.046)月,中位生存时间8月,P值分别为0.039 5、0.032 6.结论:儿童与成人Ph阳性急淋临床表现相似,预后较差.巩固强化治疗使用大剂量Ara-C、含CTX/VP16的方案可能取得相对较好的疗效,但由于例数尚少,尚难下定论.
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