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PLASMA LIPID ALTERNATION IN CHRONIC MYELOGENOUS LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.04.005
- Key Word:
- 慢性粒细胞白血病;血脂;脂蛋白;载脂蛋白
Abstract： 目的:了解慢性粒细胞白血病(CML)患者的血脂变化规律.方法:收集中山医科大一院1997年9月-2000年6月的初治CML病例,共127例.检测TC、TG、HDL、LDL、apoA1、apoB和apoA1/apoB.结果:CML加速期和急变期患者的TC、TG、HDL、LDL、apoA1、apoB较正常或CML慢性期患者明显降低(P＜0.05),TG和apoA1/apoB则明显升高(P＜0.05),若经治疗达到完全缓解(CR)则各指标恢复正常水平(P＞0.05).加速期和急变期之间、慢性期与正常对照之间各指标无明显区别(P＞0.05),急性变中急淋变与急粒变无明显差异(P＞0.05).结论:检测血脂有可能成为慢性粒细胞白血病患者病情监测、追踪随访,特别是加速期和急变期患者疗效判断的一项有重要意义的敏感指标.
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