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STUDIES ON QUERCETIN INDUCTION OF NB4 CELL INHIBITION AND APOPTOSIS
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.04.004
- Key Word:
- 槲皮素;NB4细胞;细胞凋亡
Abstract： 目的:研究黄酮类化合物槲皮素对白血病细胞株NB4的抑制作用.方法:应用细胞计数、细胞形态、DNA凝胶电泳等方法,在体外研究槲皮素诱导NB4细胞凋亡的作用.结果:10 μmol/L浓度的槲皮素无明显抑制NB4增殖作用,过高的浓度可能发生细胞变性,而当作用浓度为30μmol/L～90 μmol/L时,就能显示抑制效应,其抑制作用呈剂量依赖性,细胞表现典型的凋亡特征.结论:槲皮素在一定的浓度范围内能抑制NB4细胞增生,其作用随时间和浓度增加而增强,并诱导凋亡.
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