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STUDY ON THE REVERSING EFFECT OF O6-BENZYLGUANINE ON MULTIDRUG RESISTANT CELL LINE K562/DOX
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.03.006
- Key Word:
- O6-苄基鸟嘌呤;药物耐受性;白血病
Abstract： 目的:寻找有效的多药耐药逆转剂.方法:以O6-苄基鸟嘌呤(O6-BG)作为耐药逆转剂,用MTT法体外药物敏感试验,观察06-BG对多药耐药白血病细胞株K562/DOX的药物敏感性的影响.结果:O6-BG可增强阿霉素(DOX)对K562/DOX及K562的细胞毒作用.结论:O6-BG是一种有效的多药耐药逆转剂.
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