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EFFECTS OF LONG-TERM COMBINED CHEMOTHERAPY ON SISTER CHROMATID EXCHANGE IN THE PATIENTS WITH ADULT LEUKEMIA
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.03.004
- Key Word:
- 姐妹染色单体交换;化疗;白血病
Abstract： 目的:探讨长期联合化疗对缓解期成人白血病患者是否有潜在的诱变性.方法:应用姐妹染色单体交换(SCE)技术检测44例白血病患者外周血细胞SCE率的改变.结果:初治、复发的急性白血病(AL)和CML组患者SCE频率明显高于CR-AL组和正常对照组;CR-AL仍有少部分高SCE病例(5/16),而此类病例主要分布在接受联合化疗在9个疗程以上的CR-AL的患者中(3/6).结论:初治、复发AL和CML患者存在着DNA的损伤或DNA修复机制缺陷,长期反复联合化疗可能引起部分病例DNA的不稳定.
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