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MULTIDRUG RESISTANCE REVERSAL OF K562/VCR BY SIMULTANEOUS APPLICATION OF TETRANDRINE AND TAMOXIFEN
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.02.003
- Key Word:
- 多药耐药逆转;多药耐药基因;长春新碱;汉防己甲素;他莫西芬
Abstract： 目的:研究多药耐药基因(mdr1)及P-糖蛋白(Pgp)单独及联合应用汉防己甲素(Tet)和他莫西芬(Tmx)时,逆转多药耐药的效应.方法:使用MTT法对长春新碱(VCR)、Tet、Tmx单独及联合使用时抑制K562和K562/VCR细胞株的作用进行研究.结果:当单独及联合使用Tet和Tmx时,它们不会增加VCR对K562细胞株的抑制率,但能明显逆转K562/VCR细胞株对VCR的多药耐药.结论:Tet和Tmx单独使用均能逆转多药耐药,联合使用具有明显的协同作用.
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