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EFFECTS OF ALP ON THE PROLIFERATION AND CHEMOSENSITIVITY OF HL-60 CELLS
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- Author:
- No author available
- Journal Title:
- JOURNAL OF LEUKEMIA & LYMPHOMA
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1009-9921.2001.01.008
- Key Word:
- 抗肿瘤药物;醚酯;烷化溶血磷脂
Abstract： 目的:探讨烷化溶血磷脂(ALP)对HL60细胞生长及药物敏感性的影响.方法:以ALP对HL 60细胞克隆形成率及生长曲线影响来反映它的抗增殖效应.用MTT法检测HL60细胞对ALP及其他化疗药物敏感性.结果:ALP能显著抑制HL60细胞的增殖能力,并且呈时间、剂量依赖性.ALP与阿糖胞苷、氨甲蝾呤联合用药产生相加效应;与柔红霉素、地塞米松、三尖杉酯碱产生协同效应.结论:ALP可抑制HL-60细胞增殖,增强HL-60细胞的药物敏感性.
- [1]A, Noseda,M E, Berens,J G, White,etc.In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells.[J].1988,48.
- [2]A, Atema,K J, Buurman,E, Noteboom,etc.Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH.[J].1993,54.
- [3]高清芳等主编.现代临床药学[M].1997.
- [4]Verdonck LF,van Heugten HG.Ether lipids are effective cytotoxic drugs against multidrug-resistant acute leukemia cells and can act by the induction of apoptosis.[J].1997,21(1).
- [5]陈燕,李崇渔,喻东姣.粒系祖细胞对阿糖胞苷、三尖杉酯碱敏感性的初步报告[J].1988,(2).
- [6]Simon S.,Roy D.,Schindler M..Intracellular pH and the control of multidrug resistance.[J].1994.
- [7]吴军正.细胞培养[M].1998.