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EFFECTS OF HUMAN HOMEOBOX B1 GENE TRANSFER INTO HL-60 CELLS ON APOPTOSIS INDUCED BY RETINOIC ACID

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Author:
No author available
Journal Title:
JOURNAL OF LEUKEMIA & LYMPHOMA
Issue:
1
DOI:
10.3760/cma.j.issn.1009-9921.2001.01.005
Key Word:
同源盒基因B1;视黄酸代谢;bc1-2表达;白血病细胞

Abstract: 目的:探讨细胞内HoxB1表达、视黄酸(RA)代谢与细胞凋亡的相互关系.方法:采用脂质体介导的质粒转染和反转录-PCR等实验技术方法做有关分析检测.结果:2.5×10-7mol/L全反式RA(ATRA)处理HL-60细胞3天,HPLC分析显示,HoxB1的高表达可明显抑制HL-60细胞ATAR代谢;使ATRA增殖抑制作用减弱;野生型HL-60细胞有较强bcl-2表达,ATRA处理抑制未转染细胞bcl-2表达,但单纯HoxB1转染、HoxB1转染+IFNα均能增强bcl-2表达.结论:HoxB1转染HL-60细胞ATRA代谢明显受抑,ATRA增殖抑制作用及凋亡诱导作用减弱.

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