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The Changes of Placental Nitric Oxide Synthase Activities in Patients with Pregnancy-induced Hypertension

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
2
DOI:
10.3760/cma.j.issn.1007-9408.1999.02.005
Key Word:
一氧化氮合酶;活性;妊高征;酶组织化学

Abstract´╝Ü 目的 探讨胎盘中一氧化氮合酶(NOS)活性在妊高征发病中的作用.方法 采用酶组织化学法(四唑盐法)研究了32例妊高征患者胎盘和32例正常足月孕胎盘中一氧化氮合酶(NOS)活性的变化情况.结果 1.在正常足月孕胎盘和妊高征患者胎盘的绒毛血管内皮细胞和绒毛合体滋养细胞的胞浆内均存在NOS活性.2.妊高征患者胎盘中NOS活性显著低于正常足月孕者(P<0.05),且轻度妊高征患者胎盘中NOS活性显著高于中度及重度患者(P<0.025,P<0.025).3.妊高征患者血压与NOS活性之间存在显著的负相关(P<0.01).结论 NOS活性降低在妊高征发病中起重要作用.

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