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The level of 8-iso-prostaglandin F2α(8-iso-PGF2α)in the central obese patients with normal glucose tolerance (NGT)and its relationship with insulin resistance

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向心性肥胖;8-异前列腺素;氧化应激;胰岛素抵抗;Central obesity;8-iso-prostaglandins F2α; Oxidative stress; Insulin resistance

Abstract´╝Ü Objective To investigate the level of 8-iso-prostaglandin F2α(8-iso-PGF2α)and its relationship with insulin resistance in central obese patients with NGT. Methods Two hundred and twenty-two subjects were enrolled and divided into two groups: central obese group (n=123) and normal control group(NC, n=99). The central obese group was subdivided into insulin resistance(IR) group and non-IR group. Serum 8-iso-PGF2α, malondialdehyde (MDA), free fatty acids (FFA), IL-6, TNF-α, and lipid were measured. Results Compared with the control group, the levels of 8-iso-PGF2α(P= 0.001), body mass index(BMI), waist circumference(WC), triglyceride (TG), cholesterol (TC), high density lipoprotein(HDL), FFA, MDA and insulin resistance index (HOMA-IR) significantly increased in obese group(all P<0.05), and they increased even more in IR sub-group than those in non-IR sub-group.The level of 8-iso-PGF2α had independently positive correlation with HOMA-IR. Conclusion Oxidative stress increases in central obese patients with NGT,and it plays an important role in insulin resistance. The level of serum 8-iso-PGF2α is a better parameter indicating the extent of oxidative stress.

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