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Research status of the relationship between endothelin system and retinal vein occlusion

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Author:: No author available

Journal Title:: Chinese Journal of Ocular Fundus Diseases

Issue:: 5

DOI:: 10.3760/cma.j.cn511434-20180806-00273

Key Word:: 受体，内皮素A;视网膜静脉闭塞／病因学;静脉压;综述;Receptor, endothelin A;Retinal vein occlusion/etiology;Venous pressure;Review

Abstract： Retinal vein occlusion (RVO) is characterized by obstruction of retinal vein blood flow, distended flexion, retinal hemorrhage, edema, and neovascularization, and its pathogenesis is not completely clear. Recent studies have found that endothelin (ET)-1, ETA receptor and ETA signaling pathways in the ET system may be involved in the occurrence and development of RVO by stimulating vasoconstriction to increase retinal vein pressure and inducing the expression of pro-inflammatory factors such as TNF-α, IL-6 and IL-1β. In-depth understanding of the correlation between the ET system and the occurrence and development of RVO can provide new ideas for further research on the pathogenesis of RVO.

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