Paper - WANFANG MED ONLINE

You Position: Home > Paper

Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration

( views:101, downloads:155 )

Author:: No author available

Journal Title:: Chinese Journal of Ocular Fundus Diseases

Issue:: 4

DOI:: 10.3760/cma.j.cn511434-20180704-00226

Key Word:: 湿性黄斑变性/病因学;脉络膜新生血管化/病因学;尼古丁;综述;Wet macular degeneration/etiology;Choroidal neovascularization/etiology;Nicotine;Review

Abstract： Choroidal neovascularization is the leading causes of central vision loss in wet age-related macular degeneration (wAMD) patients. Smoking not only aggravates the incidence and severity of the choroidal neovascularization of wAMD, but also affects the clinical treatment, making the prognosis worse. Nicotine, as an important harmful substance in tobacco, is an easily addictive and highly toxic alkaloid. Animal experiments and clinical studies have confirmed that nicotine can aggravate wAMD by mediating angiogenesis through nicotinic acetylcholine receptor, bone marrow blasts, inflammation, complement system, etc. Therefore, in order to early take appropriate intervention measures to prevent and delay the development, we should actively explore the exact pathogenesis by which nicotine aggravates the choroidal neovascularization.

Reference

[1]Csaky, K. G.,Baffi, J. Z.,Byrnes, G. A.,etc.Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor[J].2004,78(6).
[2]D P, Richman,B G, Arnason.Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.[J].1979,76(9).
[3]Sara, Velilla,José Javier, García-Medina,Alfredo, García-Layana,etc.Smoking and age-related macular degeneration: review and update.[J].2013,2013.
[4]Kent DL,Hiscott PS,Wong D,etc.The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization.[J].2006,47(4).
[5]Lincoln V Johnson,William P Leitner,Michelle K Staples,etc.Complement Activation and Inflammatory Processes in Drusen Formation and Age Related Macular Degeneration[J].2001,73(6).
[6]Delcourt C\u00e9cile.Smoking and Age-related Macular Degeneration[J].1998.
[7]Zuoyi Shao,Jerrel L. Yakel.Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices[J].2000,527(3).
[8]Lim,L.S.,Mitchell,P.,Seddon,J.M.,etc.Age-related macular degeneration[J].2012,379(9827).
[9]B V, Sastry,M E, Hemontolor.Influence of nicotine and cotinine on retinal phospholipase A2 and its significance to macular function.[J].1998,14(5).
[10]Davis,S.J.,Lyzogubov,V.V.,Tytarenko,R.G.,etc.The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration[J].2012,32(6).
[11]Heeschen C,Cooke JP,Chang E,etc.Endothelial progenitor cells participate in nicotine-mediated angiogenesis.[J].2006,48(12).
[12]Jeffrey Crosby,Wolfgang Kaminski,Gina Schatteman,etc.Endothelial Cells of Hematopoietic Origin Make a Significant Contribution to Adult Blood Vessel Formation[J].2000,87(9).
[13]Martin K.C. Ng,Jenny Wu,Edwin Chang,etc.A Central Role for Nicotinic Cholinergic Regulation of Growth Factor\u2013Induced Endothelial Cell Migration[J].2006,27(1).
[14]Rapp,J.,Willeford,K.T..Smoking and age-related macular degeneration: Biochemical mechanisms and patient support[J].2012,89(11).
[15]Lechanteur, Yara T. E.,van de Camp, Patrick L.,Smailhodzic, Dzenita,etc.Association of Smoking and CFH and ARMS2 Risk Variants With Younger Age at Onset of Neovascular Age-Related Macular Degeneration[J].2015,133(5).
[16]Hong Li,Tian Yang,Qian Ning,etc.Cigarette smoke extract–treated mast cells promote alveolar macrophage infiltration and polarization in experimental chronic obstructive pulmonary disease[J].2015,27(14).
[17].VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization.[J].2017.
[18]H, Kurzen,I, Wessler,C J, Kirkpatrick,etc.The non-neuronal cholinergic system of human skin.[J].2007,39(2).
[19]Wu JC,De Jesus Perez VA,Chruscinski A.Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor.[J].2009,108(2).
[20]A C, Villablanca.Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro.[J].1998,84(6).
[21]Jian, Liu,David A, Copland,Sofia, Theodoropoulou,etc.Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.[J].2016.
[22]Alejandro Caicedo,Diego G. Espinosa-Heidmann,Yolanda Piña,etc.Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization[J].2005,81(1).
[23]Alex Woodell,Barbel Rohrer.A Mechanistic Review of Cigarette Smoke, and Age-Related Macular Degeneration[J].2014,801.
[24]Kwak N,Wood JM,Okamoto N,etc.VEGF is major stimulator in model of choroidal neovascularization.[J].2000,41(10).
[25]Jha P,Kaliappan S,Bora PS,etc.CD59, a Complement Regulatory Protein, Controls Choroidal Neovascularization in a Mouse Model of Wet-Type Age-Related Macular Degeneration.[J].2007,178(3).
[26]Moracco, Kathryn E.,Morgan, Jennifer C.,Mendel, Jennifer,etc."My First Thought was Croutons": Perceptions of Cigarettes and Cigarette Smoke Constituents Among Adult Smokers and Nonsmokers[J].2016,18(7).
[27]Lee,S.,Song,S.J.,Yu,H.G..Current smoking is associated with a poor visual acuity improvement after intravitreal ranibizumab therapy in patients with exudative age-related macular degeneration[J].2013,28(5).
[28]Jieun Lee,John P Cooke.Nicotine and pathological angiogenesis.[J].2012,91(21).
[29]Kaliappan S,Bora PS,Dhaulakhandi DB,etc.Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.[J].2006,177(3).
[30]Mrazek D,Tombran-Tink J,Uetama T,etc.Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF.[J].2001,189(3).
[31]Jason X.-J. Yuan,Carmelle V. Remillard,Amy L. Firth.TRP channels in hypertension[J].2007,1772(8).
[32]Takayuki Asahara,Tomono Takahashi,Haruchika Masuda,etc.VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells[J].2002,18(14).
[33]Pereira EF,Conti Fine BM,Diethelm Okita BM,etc.A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes.[J].1995,105(6).
[34]Hou HY,Wang BR,Wang YS,etc.Nicotine promotes contribution of bone marrow-derived cells to experimental choroidal neovascularization in mice.[J].2008,86(6).
[35]Bernd Nilius,Guy Droogmans,Robert Wondergem.Transient Receptor Potential Channels in Endothelium: Solving the Calcium Entry Puzzle?[J].2003,10(1).
[36]Kathleen C. Brown,Jamie K. Lau,Aaron M. Dom,etc.MG624, an \u03b17-nAChR antagonist, inhibits angiogenesis via the Egr-1\/FGF2 pathway[J].2011,15(1).
[37]Geeta Sharma,Sukumar Vijayaraghavan.Nicotinic receptor signaling in nonexcitable cells[J].2002,53(4).
[38]Lau,J.K.,Buckley,A.W.,Dasgupta,P.,etc.The α7-nicotinic acetylcholine receptor and MMP-2/-9 pathway mediate the proangiogenic effect of nicotine in human retinal endothelial cells[J].2011,52(7).
[39]S, Leonard,D, Bertrand.Neuronal nicotinic receptors: from structure to function.[J].2001,3(3).
[40].Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells.[J].2017.
[41]Jack, Shao,Maria M, Choudhary,Andrew P, Schachat.Neovascular Age-Related Macular Degeneration.[J].2016,55.
[42]Kim D. Janda,Grant E. Boldt,Andrew P. Brogan,etc.Altered retinoid homeostasis catalyzed by a nicotine metabolite: Implications in macular degeneration and normal development[J].2005,102(30).
[43]A, Karlin,M H, Akabas.Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.[J].1995,15(6).
[44]J R, Vingerling,A, Hofman,D E, Grobbee,etc.Age-related macular degeneration and smoking. The Rotterdam Study.[J].1996,114.
[45]Maugeri, Grazia,D'Amico, Agata Grazia,Rasa, Daniela Maria,etc.Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema[J].2017,44.
[46]Jha P,Kaliappan S,Sohn JH,etc.Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization.[J].2005,174(1).
[47]Pereira EF,Maus AD,Conti-Fine BM,etc.Human vascular endothelial cells express functional nicotinic acetylcholine receptors.[J].1998,287(1).
[48]Suner IJ,Espinosa Heidmann DG,Marin Castano ME,etc.Nicotine increases size and severity of experimental choroidal neovascularization.[J].2004,45(1).
[49]Marin Castano ME,Pons M.Nicotine Increases the VEGF/PEDF Ratio in Retinal Pigment Epithelium: A Possible Mechanism for CNV in Passive Smokers with AMD.[J].2011,52(6).
[50]Cooke JP,Heeschen C,Dimmeler S,etc.A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.[J].2002,110(4).