Abstract: The pathogenesis of diabetic retinopathy (DR) is complicated and has not yet been fully elucidated.To explore the pathogenesis of DR and the mechanism of drug action,proteomics through quantitative analysis techniques is very useful.It can analyzes differentially expressed proteins in the retina,vitreous fluid,aqueous humor,tears,and blood of DR patients and diabetic rats,and analyzes differentially expressed proteins after drug intervention.This paper is a review of the progress in proteomic research of DR in recent years.