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Role of stromal cell derived factor-1/CXC chemokine receptor 4 pathway in mesenchymal stem cells therapies in the management of diabetic retinopathy

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Author:: No author available

Journal Title:: Chinese Journal of Ocular Fundus Diseases

Issue:: 6

DOI:: 10.3760/cma.j.issn.1005-1015.2016.06.029

Key Word:: 糖尿病视网膜病变/治疗;趋化因子CXCL12;受体,CXCR4;间质干细胞;综述;Diabetic retinopathy/therapy;Chemokine CXCL12;Receptors,CXCR4;Mesenchymal stem cells;Review

Abstract： Mesenchymal stem cells (MSC) are considered to have important value in the treatment of various diseases because of their low immunogenicity,transferability,and strong tissue repair capacity.Stromal cell derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) pathway plays an important role in migration of MSC.The induction of homing of MSC to retina by regulating SDF-1/CXCR4 may exert the curative effect on diabetic retinopathy to greatest exent.

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