Abstract： Objective To observe the changes of tortuosity and bifurcation angle of retinal arteries and veins in each quadrant of the posterior pole in eyes with high myopia. Methods The tortuosity and bifurcation angle of retinal vessels in each quadrant of the posterior pole in 32 patients (52 eyes) with high myopia and 22 healthy people (30 eyes) were observed and compared. The outcomes were analyzed by multivariate analysis of variance. Results The tortuosity of macular vessels and the artery from optic disc in eyes with high myopia was (1.29±1.10)×10-4 and (5.39±1.93)×10-5 respectively, and in the normal eyes was (4.15±2.38)×10-4 and (9.75±4.99)×10-5 respectively; there was significant difference between the two groups (t=1.99, 2.00; P<0.05). The bifurcation angle of superior nasal and inferior nasal retinal arteries in eyes with high myopia was(66.17±14.04)° and (61.20±11.02)° respectively, and in the normal eyes was (77.66±14.12)° and (85.86±16.45)° respectively; there was significant difference between the two groups (F=0.77, 0.83; P<0.05). The bifurcation angle of superior temporal and inferior temporal retinal veins in eyes with high myopia was (92.39±20. 36)° and (83.56±23.50)° respectively, and in the normal eyes was (79.45±15.94)° and (70.59±17.27)°; there was significant difference between the two groups (F=2.34, 1.83; P<0.05). Conclusions The vessel tortuosity of retinal arteries and the vessels extending from the optic disc to macula is smaller in eyes with high myopia, while the venous tortuosity has no change. The bifurcation angle of retinal arteries in the superior nasal and inferior nasal field was smaller in eyes with high myopia, while the venous tortuosity has no change. The bifurcation angle of retinal veins in the superior temporal and inferior temporal field was larger in eyes with high myopia.