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高糖对牛视网膜微血管内皮细胞一氧化氮产生的影响
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 4
- DOI:
- No doi available
- Key Word:
- 糖尿病视网膜病变/病理生理学;内皮细胞;一氧化氮;动物实验
Abstract： @@ 糖尿病视网膜病变(DR)时视网膜微循环结构和功能的改变是非常重要的病理生理过程.血管内皮生长因子(VEGF)与糖尿病视网膜微循环结构和功能的改变存在密切关系[1,2].有研究显示,VEGF增高与一氧化氮(NO)呈直线正相关,提示NO可促使VEGF的表达,而VEGF也促使NO的产生,两者之间存在着正反馈[3];亦有研究认为VEGF可能通过NO的介导而导致血管内皮损伤[4].抑制NO合酶活性可阻抑糖尿病诱导的硝基酪氨酸形成并下调糖尿病引起的VEGF升高,避免血视网膜屏障破坏[5].因此,高水平NO可能是引起内皮细胞损伤的重要原因.我们采用体外培养的牛视网膜微血管内皮细胞(BREC)研究高糖对其NO产生的影响,现将结果报告如下.
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