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神经生长因子-β、脑源性神经营养因子、胶质细胞源性神经营养因子对体外压力作用下视网膜神经细胞的保护作用
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1005-1015.2004.04.014
- Key Word:
- 视网膜神经细胞;生长物质;压力
Abstract： @@ 高眼压是青光眼最主要的致病因素,青光眼的视野丧失是节细胞死亡的结果,供应视网膜的神经营养因子被剥夺、细胞内离子的失衡等参与了细胞的损害过程[1].神经生长因子(NGF)、脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)、睫状节神经营养因子(CNTF)等可减少实验性高眼压缺血、视神经切断后的视网膜神经节细胞的死亡[2].为寻找更多的证据或新的保护剂,有必要对可能的青光眼视功能的保护剂进行进一步的研究.
- [1]H, Gao,X, Qiao,F, Hefti,etc.Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury.[J].1997,38.
- [2]G M, Bray,M P, Villegas-Pérez,M, Vidal-Sanz,etc.Neuronal and nonneuronal influences on retinal ganglion cell survival, axonal regrowth, and connectivity after axotomy.[J].1991,633.
- [3]Elena Vecino,Marta Ugarte,Mark Nash,etc.NMDA induces BDNF expression in the albino rat retinain vivo[J].1999,10(5).
- [4]Urich JL,Wang J,Matheson CR,etc.Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF).[J].1999,38(3).
- [5]Tomita H.,Abe T.,Tamai M.,etc.Increased expression of low-affinity NGF receptor in rat retinal Muller cells after ischemia and reperfusion[J].1998,23(4).