Abstract： Pancreatic cancer is a malignant disease with an extremely poor prognosis. For now, radical resection is the only long-term survival approach. Therefore, for complete resection of different types of pancreatic neoplasms, scholars and surgeons have innovated and applied numerous surgical methods. Aiming at various situations, a large amout of methods and principles have been suggested. Unresectable neoplasms have been challenged day by day. Meanwhile, with the progression of technology, minimally invasive techniques have been applied to resection of pancreatic neoplasms. This article mainly reviews the innovation of surgical methods and technology in radical surgery of pancreatic cancer in recent years.