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Effect of materal anti-Sj?gren's syndrome type A/Sj?gren's syndrome type B antibodies on fetal heart development and the management

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Author:
No author available
Journal Title:
Chinese Journal of Perinatal Medicine
Issue:
12
DOI:
10.3760/cma.j.cn113903-20220719-00722
Key Word:
抗体,抗核;自身抗原;核糖核蛋白类;胎儿心脏;心脏传导阻滞;心脏病;产前诊断;胎儿期疗法;Antibodies, antinuclear;Autoantigens;Ribonucleoproteins;Fetal heart;Heart block;Heart diseases;Prenatal diagnosis;Fetal therapies

Abstract: Anti-Sj?gren's syndrome type A(SSA) and anti-Sj?gren's syndrome type B(SSB) antibodies both belong to the antinuclear antibody spectrum and are common in patients with systemic lupus erythematosus, Sj?gren's syndrome and undifferentiated connective tissue disease as well as asymptomatic patients. Approximately 1% of pregnant women are positive for anti-SSA and anti-SSB antibodies and only 1%-3% of the fetuses carried by primiparae with anti-SSA and anti-SSB antibodies show immune-mediated cardiac conduction and structural abnormalities. Due to its low incidence and insidious onset, some pregnant women were diagnosed positive for antibodies against SSA and SSB for the first time only due to fetal heart block or structural abnormalities during pregnancy. Domestic and international research on the effects of anti-SSA and anti-SSB antibodies on fetal heart and the prenatal monitoring, diagnosis, intrauterine treatment and prognosis of fetal cardiac abnormalities related to anti-SSA and anti-SSB exposure are reviewed to guide the clinical work of obstetrics.

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