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Recent advance in Toll-like receptor 4 related signaling pathway in inflammatory injury of ischemic stroke

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Journal Title:
Chinese Journal of Neuromedicine
Key Word:
Toll样受体4;缺血性脑卒中;炎症损伤;Toll-like receptor 4;Ischemic stroke;Inflammatory damage

Abstract´╝Ü The mechanism of ischemic stroke development has not been fully elucidated, but inflammatory damage has been recognized to play an important role. Activation of Toll-like receptor 4 (TLR4)-related signaling pathways can promote the expressions of pro-inflammatory cytokines and anti-inflammatory cytokines associated with ischemic stroke, thereby affecting the progression and prognosis of ischemic stroke. The author reviews the research progress of TLR4-related signaling pathways in inflammatory injury of ischemic stroke, in order to provide some ideas and references for the discovery of targeted TLR4 anti-inflammatory drugs that can be used for ischemic stroke treatment.

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