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Recent advance in treatment of refractory epilepsy by reactive nerve stimulation

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Journal Title:
Chinese Journal of Neuromedicine
Key Word:
神经调控;反应性神经刺激;难治性癫痫;Neuromodulation;Responsive neurostimulation;Refractory epilepsy

Abstract´╝Ü Neuromodulation techniques as vagus nerve stimulation (VNS) and deep brain stimulation (DBS) play important roles in treating refractory focal epilepsy. In recent years, epileptogenic zone closed-loop responsive neurostimulator system (RNS) has been gradually put into clinical practice; in 2013, it was approved by U.S. Food and Drug Administration (FDA) as an adjuvant therapy for refractory epilepsy. This article reviews the development history, clinical application, anti-epileptic mechanism and future research directions of RNS to deepen the understanding of clinical workers.

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