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Research progress of relationship between acromegaly and metabolic syndrome

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Author:: No author available

Journal Title:: China Medicine

Issue:: 2

DOI:: 10.3760/j.issn.1673-4777.2023.02.034

Key Word:: 肢端肥大症;代谢综合征;肥胖;胰岛素抵抗;糖尿病;高血压

Abstract：肢端肥大症是内分泌科和神经外科罕见的内分泌紊乱性疾病,可使生长激素和胰岛素样生长因子1(IGF-1)分泌过量导致全身多系统受损,引起肥胖、胰岛素抵抗、糖尿病、高血压、血脂异常等代谢紊乱,并增加心血管疾病风险,严重影响患者的生活质量和预期寿命.研究发现,肢端肥大症患者代谢综合征及其各组分的发病率显著高于一般人群,其发病机制多与生长激素和IGF-1 水平升高相关.本文旨在对肢端肥大症合并代谢综合征及其各组分的流行病学特征、致病机制和治疗等进行综述,以期引起临床重视并加深认识,为疾病防治提供依据.

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