The value of global registry of acute coronary events score combined with serum soluble interleukin-6 receptor level in predicting postoperative major adverse cardiovascular events in patients with acute myocardial infarction
- Author:
- No author available
- Journal Title:
- China Medicine
- Issue:
- 2
- DOI:
- 10.3760/j.issn.1673-4777.2023.02.005
- Key Word:
- 急性心肌梗死;全球急性冠状动脉事件注册评分;可溶性白细胞介素 6 受体;主要不良心血管事件
Abstract： 目的 探讨全球急性冠状动脉事件注册(GRACE)评分联合血清可溶性白细胞介素 6 受体(sIL-6R)水平对急性心肌梗死(AMI)患者术后主要不良心血管事件(MACE)发生风险的预测价值.方法 选取2020 年6 月至2021 年6 月福建省立医院收治的116 例行经皮冠状动脉介入治疗的AMI患者,根据术后6 个月内是否发生MACE分为MACE组和无MACE组.入院后进行GRACE评分,采用酶联免疫吸附试验法检测患者血清sIL-6R水平,比较2 个指标和一般资料的组间差异,分析GRACE评分联合sIL-6R水平对AMI患者术后MACE发生风险的预测价值.结果 无MACE组纳入81 例患者,MACE组纳入35 例患者.MACE组患者心率、心力衰竭病史比例均高于无MACE组,舒张压、收缩压均低于无MACE组(均P<0.05).MACE组患者GRACE评分和血清sIL-6R水平均高于无MACE组(均P<0.001).多因素Logistic回归分析结果显示,GRACE评分≥138 分(比值比=2.843,95%置信区间:1.498~5.397)、血清sIL-6R水平≥439.56 kU/L(比值比=3.121,95%置信区间:1.373~7.094)是AMI患者术后发生MACE的独立危险因素(均P<0.05).受试者工作特征曲线分析结果显示,GRACE评分和血清sIL-6R水平联合预测AMI患者术后MACE发生风险的曲线下面积为 0.861(95%置信区间:0.823~0.889),敏感度和特异度分别为83.54%和76.22%.结论 AMI术后发生MACE患者GRACE评分和血清sIL-6R水平升高,二者联合对AMI术后MACE发生风险具有较好预测价值.
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