Expression and clinical significance of serum relaxin 2 and calponin 1 in patients with unstable angina pectoris complicated with type 2 diabetes mellitus
- Author:
- No author available
- Journal Title:
- China Medicine
- Issue:
- 2
- DOI:
- 10.3760/j.issn.1673-4777.2023.02.004
- Key Word:
- 不稳定型心绞痛;2 型糖尿病;松弛素2;钙调理蛋白1
Abstract： 目的 探讨不稳定型心绞痛(UAP)合并2 型糖尿病(T2DM)患者血清松弛素 2 及钙调理蛋白1(CNN1)的表达及临床意义.方法 选取2018 年2 月至2020 年2 月在湖北省武汉市红十字会医院诊治的120 例UAP患者为研究对象,根据是否有T2DM分为UAP组(62 例)和UAP合并T2DM组(58 例).采用酶联免疫吸附试验法检测2 组患者血清松弛素2、CNN1 水平.比较2 组一般临床资料及血清松弛素2、CNN1 水平.分析UAP合并T2 DM患者血清松弛素2、CNN1 与临床指标的相关性.采用多因素Logistic回归分析影响UAP合并T2 DM发生的因素.采用受试者工作特征曲线分析血清松弛素2、CNN1 单独及联合检测对UAP合并T2DM的预测价值.结果 UAP 合并 T2DM 组三酰甘油、空腹血糖、高敏 C 反应蛋白(hs-CRP)、Gensini评分、松弛素2 及CNN1 水平均明显高于UAP组(均P<0.05).UAP合并T2DM患者血清松弛素2 与空腹血糖、hs-CRP呈显著正相关,CNN1 与空腹血糖、hs-CRP和Gensini评分呈显著正相关(均P<0.05).松弛素 2(比值比 =1.347,95%置信区间:1.085~1.674,P = 0.008)、CNN1(比值比 = 2.172,95%置信区间:1.098~4.296,P=0.007)是影响UAP合并T2DM发生的独立因素.血清松弛素 2、CNN1 单独及联合检测对UAP合并T2 DM预测的曲线下面积为 0.769、0.786、0.875,血清松弛素 2、CNN1联合检测预测的曲线下面积显著高于血清松弛素 2、CNN1 单独检测(Z =3.810、3.509,均P<0.001).结论 UAP合并T2DM患者血清松弛素2、CNN1 表达升高,松弛素2、CNN1 是影响UAP合并T2 DM发生的相关因素,血清松弛素2、CNN1 联合检测对UAP合并T2 DM具有较高的预测价值.
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