Relationship of serum levels of long non-coding RNA nuclear enriched abundant transcript 1 and soluble intercellular adhesion molecule-1 with coronary slow flow phenomenon
- Author:
- No author available
- Journal Title:
- China Medicine
- Issue:
- 12
- DOI:
- 10.3760/j.issn.1673-4777.2022.12.004
- Key Word:
- 冠状动脉慢血流;长链非编码RNA核富集转录体1;可溶性细胞间黏附分子1
Abstract： 目的 探讨血清长链非编码RNA核富集转录体1(NEAT1)及可溶性细胞间黏附分子1(sICAM-1)水平与冠状动脉慢血流现象(CSFP)的关系.方法 选择2020年8月至2022年2月在四川省遂宁市中心医院疑诊为冠状动脉粥样硬化性心脏病而行冠状动脉造影检查的患者,以其中造影未见明显病变的110例为研究对象,将心肌梗死溶栓试验(TIMI)血流分级2级及以下且无冠状动脉狭窄、诊断为CSFP的70例患者作为CSFP组,以TIMI血流分级3级且无冠状动脉明显狭窄者40例作为对照组.利用荧光定量聚合酶链反应法检测血清NEAT1表达,酶联免疫吸附试验法检测血清sICAM-1表达.比较2组NEAT1及sICAM-1表达差异.Pearson线性相关分析方法 分析血清NEAT1及sICAM-1水平与冠状动脉TIMI平均血流帧数的相关性.采用多因素Logistic回归方法 分析CSFP的危险因素.采用受试者工作特征曲线分析血清NEAT1、sICAM-1单独及联合检测对CSFP的诊断效能.结果 CSFP组血清NEAT1、sICAM-1表达水平高于对照组,差异均有统计学意义(均P<0.05).Pearson相关性分析结果 显示,血清NEAT1、sICAM-1表达与冠状动脉TIMI平均血流帧数呈显著正相关(r=0.456、0.503,均P<0.001).血清NEAT1与sICAM-1的表达水平呈显著正相关(r=0.541,P<0.001).有吸烟史、血清NEAT1、sICAM-1水平升高是CSFP的独立危险因素,白蛋白升高是CSFP的保护因素(均P<0.05).血清NEAT1、sICAM-1单独及联合检测诊断CSFP的曲线下面积分别为0.698(95％置信区间:0.591～0.736)、0.789(95％置信区间:0.734～0.832)、0.836(95％置信区间:0.802～0.885),联合检测诊断CSFP的曲线下面积显著高于血清NEAT1、sICAM-1单独检测(Z=2.061、P=0.039,Z=6.403、P<0.001).结论 CSFP患者血清NEAT1、sICAM-1水平升高.有吸烟史、血清NEAT1、sICAM-1水平升高是CSFP的独立危险因素,白蛋白升高是CSFP的保护因素.血清NEAT1、sICAM-1联合检测对CSFP具有较高的诊断价值.
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