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Advances on follicular helper T cells in patients with hepatitis B virus infection

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Journal Title:
Chinese Journal of Clinical Infectious Diseases
Key Word:
肝炎病毒,乙型;肝炎,乙型,慢性;滤泡辅助性T淋巴细胞;Hepatitis B virus;Chronic hepatitis B;Follicular helper T cells

Abstract´╝Ü Hepatitis B virus (HBV) infection is a major global public health problem. Persistent HBV infection is prone to develop chronic hepatitis B (CHB), and CHB is closely related to the development of liver fibrosis and hepatocellular carcinoma. High-affinity specific anti-HBs are essential for the control of HBV infection, while the antibody production is closely related to follicular helper T (Tfh) cells. Tfh cells can help B cells differentiate into plasma cells to produce specific antibodies to control virus infection. This article reviews the latest research progress of Tfh cells in HBV infection to provide information of new strategies for the prevention and treatment of HBV.

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