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A case of Leishmania infection presenting as skin lesions diagnosed by metagenomic next-generation sequencing and literature review

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Author:
No author available
Journal Title:
Chinese Journal of Clinical Infectious Diseases
Issue:
6
DOI:
10.3760/cma.j.issn.1674-2397.2021.06.006
Key Word:
利什曼原虫;宏基因二代测序;皮肤损害;Leishmania;Metagenomic next-generation sequencing;Skin damage

Abstract´╝Ü 发热是临床最常见的症状之一,有时发热的原因难以查明,致使疾病的诊治陷于困难。本文报道一例晚期T细胞淋巴瘤患者在治疗过程中出现了原发疾病不能解释的发热伴皮肤损害,使用各种传统的检测方法均未能找到发热原因,经验性使用广谱抗菌药物也未能使发热缓解。后经外周血宏基因组二代测序诊断为利什曼原虫病,该患者经过对因治疗后症状缓解。本病例显示出了宏基因组二代测序对罕见感染性疾病的诊断价值。

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