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The therapeutics and management of cryptococcus-related immune reconstitution inflammatory syndrome in AIDS patients

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 3

DOI:: 10.3760/cma.j.issn.1674-2397.2021.03.013

Key Word:: 获得性免疫缺陷综合征;隐球菌病;免疫重建炎症综合征;治疗;管理;Acquired immune deficiency syndrome;Cryptococcosis;Immune reconstitution inflammatory syndrome;Therapeutics;Management

Abstract： Acquired immune deficiency syndrome (AIDS) can cause various opportunistic infections clinically due to severe defects in the body’s cellular immune function. Cryptococcosis is a common serious opportunistic infection in AIDS patients. With the promotion and popularization of high activity antiretroviral therapy (HAART) programs worldwide, the mortality rate of AIDS-related cryptococcosis has been significantly decreased. After initiating antiviral therapy, some patients experienced recurrence and aggravation of clinical symptoms during anti-cryptococcal treatment. The body has an inflammatory response to the excessive immune regulation of cryptococcal antigens, which is called cryptococcus-related immune reconstitution inflammatory syndrome (C-IRIS). C-IRIS seriously affects the quality of life and prognosis of patients. This article reviews the clinical features, pathogenesis and the latest treatment and management strategies of C-IRIS in AIDS patients.

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