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Progress on development of vaccines against 2019-nCoV
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-2397.2021.01.003
- Key Word:
- 冠状病毒属;新型冠状病毒;疫苗;佐剂;免疫效应;Coronavirus;2019-nCoV;Vaccines;Adjuvant;Immunological effect
Abstract： Since the outbreak of COVID-19 caused by the 2019-nCoV (SARS-CoV-2), with its high pathogenicity and contagiousness, it has posed a serious threat to global public health security. Up to now, the pathogenesis of 2019-nCoV is unclear, and there is no effective treatment. Vaccine as one of the most effective strategies to prevent virus infection has become a hot area. Based on the current understanding of 2019-nCoV, the development of 2019-nCoV vaccines covers all types: inactivated virus vaccine, recombinant protein vaccine, viral vector-based vaccine, mRNA vaccine, and DNA vaccine, etc. In this review, we focus on the candidate targets of the novel coronavirus, and the types, development status and progress of 2019-nCoV vaccines in order to provide information for further research and prevention.
- [1]Xiaojuan Guo,Yao Deng,Hong Chen,etc.Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector‐based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus[J].2015,145(4).
- [2]于琨,安丽平,王伟,等.流感疫苗的研究进展[J].2017,(14).
- [3]Anthony R, Fehr,Stanley, Perlman.Coronaviruses: an overview of their replication and pathogenesis.[J].2015,1282.
- [4]Alina Baum,Adolfo Garcfa-Sastre.Induction of type I interferon by RNA viruses: cellular receptors and their substrates[J].2010,38(5).
- [5]Syed Faraz,Ahmed,Ahmed A,Quadeer,Matthew R,McKay.Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.[J].2020,12(3).
- [6]Pacchione SJ,Wang X,Wang Z,etc.Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation.[J].2004,11(8).
- [7]Miao Lei,Li Linxian,Huang Yuxuan,etc.Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation[J].2019,37(10).
- [8]Murphy BR,Elkins WR,Bukreyev A,etc.Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.[J].2004,363(9427).
- [9]Victor M, Corman,Doreen, Muth,Daniela, Niemeyer,etc.Hosts and Sources of Endemic Human Coronaviruses.[J].2018,100(Spec ).
- [10].Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein[J].2015,89(16).
- [11]Fang Li.Structure, Function, and Evolution of Coronavirus Spike Proteins[J].2016,3.
- [12]Manli Wang,Ruiyuan Cao,Leike Zhang,etc.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J].2020,30(3).
- [13]Dietzschold B,Koprowski H,Schnell MJ,etc.A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARS-CoV-neutralizing antibodies[J].2005,86(5).
- [14]Jianjun Gao,Zhenxue Tian,Xu Yang.Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies[J].2020,14(1).
- [15]Kim, Eun,Okada, Kaori,Kenniston, Tom,etc.Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice[J].2014,32(45).
- [16]Corman V. M.,Lienau J.,Witzenrath M..Coronaviren als Ursache respiratorischer Infektionen[J].2019,60(11).
- [17]He, Peng,Zou, Yening,Hu, Zhongyu.Advances in aluminum hydroxide-based adjuvant research and its mechanism[J].2015,11(2).
- [18]Capell, Teresa,Twyman, Richard M.,Armario-Najera, Victoria,etc.Potential Applications of Plant Biotechnology against SARS-CoV-2[J].2020,25(7).
- [19]Chappell M,Liu Y,Slutsky AS,etc.A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.[J].2005,11(8).
- [20]Poland, Gregory A.,Ovsyannikova, Inna G.,Crooke, Stephen N.,etc.SARS-CoV-2 Vaccine Development: Current Status[J].2020,95(10).
- [21]Lester,S.N.,Li,K..Toll-like receptors in antiviral innate immunity[J].2014,426(6).
- [22]McIvor RS.Therapeutic delivery of mRNA: the medium is the message.[J].2011,19(5).