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Progress on development of vaccines against 2019-nCoV

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Journal Title:
Chinese Journal of Clinical Infectious Diseases
Key Word:
冠状病毒属;新型冠状病毒;疫苗;佐剂;免疫效应;Coronavirus;2019-nCoV;Vaccines;Adjuvant;Immunological effect

Abstract´╝Ü Since the outbreak of COVID-19 caused by the 2019-nCoV (SARS-CoV-2), with its high pathogenicity and contagiousness, it has posed a serious threat to global public health security. Up to now, the pathogenesis of 2019-nCoV is unclear, and there is no effective treatment. Vaccine as one of the most effective strategies to prevent virus infection has become a hot area. Based on the current understanding of 2019-nCoV, the development of 2019-nCoV vaccines covers all types: inactivated virus vaccine, recombinant protein vaccine, viral vector-based vaccine, mRNA vaccine, and DNA vaccine, etc. In this review, we focus on the candidate targets of the novel coronavirus, and the types, development status and progress of 2019-nCoV vaccines in order to provide information for further research and prevention.

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