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Value of red cell distribution width and red cell distribution width to platelet ratio in diagnosis and prognosis of HEV-related liver failure

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-2397.2020.06.007

Key Word:: 戊型肝炎;肝衰竭;红细胞分布宽度;红细胞分布宽度与血小板比值;Hepatitis E;Liver failure;Red cell distribution width;Red cell distribution width-to-platelet ratio

Abstract：目的:探讨红细胞分布宽度(RDW)和RDW与血小板比值(RPR)在HEV相关肝衰竭诊断及预后中的价值。方法:回顾性地分析浙江大学医学院附属第一医院、盐城市第一人民医院、无锡市第五人民医院和盐城市第二人民医院2013年1月至2020年5月152例无肝衰竭HEV感染(HEV-non-LF)患者和62例HEV诱导的肝衰竭(HEV-LF)患者的临床资料。使用受试者工作特征曲线(ROC)来评估RDW和RPR对诊断HEV相关肝衰竭及其预后的能力。结果:多因素Logistic回归分析显示，RDW( OR＝1.189，95% CI 1.026～1.376)和RPR( OR＝4.758，95% CI 1.621～13.965)均为影响戊型肝炎患者发生相关肝衰竭的独立危险因素( P<0.05或<0.01)。RPR和RDW预测HEV发生相关肝衰竭的ROC曲线下面积(AUC)分别为0.73(95% CI 0.67～0.79, P<0.01)和0.68(95% CI 0.61～0.74, P<0.01)。RPR和RDW预测HEV相关肝衰竭患者预后的AUC分别为0.62(95% CI 0.49～0.74, P<0.01)和0.57(95% CI 0.44～0.70, P>0.05)。结论:RPR和RDW对HEV相关肝衰竭有一定的预测价值，RPR对肝衰竭患者预后有一定的预测价值。

Reference

[1]中华医学会感染病学分会肝衰竭与人工肝学组,中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南（2018 年版）[J].2018,(6).
[2]秦娇,强丽,陈文,等.红细胞分布宽度可作为乙型肝炎相关慢加急性肝衰竭患者短期死亡的独立预测因子[J].2018,(11).
[3]Xu-dong Liu,Jian-Lin Wu,JIAN Liang,etc.Globulin-platelet model predicts minimal fibrosis and cirrhosis in chronic hepatitis B virus infected patients[J].2012,(22).
[4]Chen, Baode,Ye, Bo,Zhang, Jian,etc.RDW to Platelet Ratio: A Novel Noninvasive Index for Predicting Hepatic Fibrosis and Cirrhosis in Chronic Hepatitis B.[J].2013,8(7).
[5]Fan, Xiude,Deng, Huan,Wang, Xiqiang,etc.Association of red blood cell distribution width with severity of hepatitis B virus-related liver diseases[J].2018,482.
[6]Wei Wu,Huadong Yan,Hong Zhao,etc.Characteristics of systemic inflammation in hepatitis B‐precipitated ACLF: Differentiate it from No‐ACLF[J].2018,38(2).
[7]WS.戊型病毒性肝炎诊断标准[S].2008.
[8]Yan-Chao Hu,Hao Liu,Xiao-Yan Liu,etc.Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B[J].2017,(41).
[9]Huang Chung‐Feng,Yeh Ming‐Lun,Huang Ching‐I,etc.Interference of hepatitis B virus dual infection in platelet count recovery in chronic hepatitis C patients with curative antiviral therapy[J].2018,33(5).
[10]Hassan, Sobia,Antonelli, Maria,Ballou, Stanley.Red cell distribution width: a measure of cardiovascular risk in rheumatoid arthritis patients?[J].2015,34(6).
[11]Jung Hyun, Kwon,Jeong Won, Jang,Young Woon, Kim,etc.The usefulness of C-reactive protein and neutrophil-to-lymphocyte ratio for predicting the outcome in hospitalized patients with liver cirrhosis.[J].2015,15.
[12]Zhu, Xuan,Lan, Fang,Li, Shan,etc.Value of Red Cell Distribution Width in Assessing the Severity of Hepatitis B Virus-Related Decompensated Cirrhosis[J].2017,63(9).
[13]Jian,Wu,Naizhou,Guo,Lifei,Zhu,etc.Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case-control study in China.[J].2020,9(1).
[14]Rui, Huang,Chenchen, Yang,Kangkang, Wu,etc.Red cell distribution width as a potential index to assess the severity of hepatitis B virus-related liver diseases.[J].2014,44(14).
[15]Zhu, Yuan O.,Aw, Pauline,Aung, Myo Myint,etc.Patterns of mutation within an emerging endemic lineage of HEV-3a[J].2019,26(1).
[16]Aktas,G.,Sit,M.,Dikbas,O.,etc.Could red cell distribution width be a marker in Hashimoto's Thyroiditis?[J].2014,122(10).
[17]Jessica Shearer,David Chizhande,Rebecca Jones,etc.Non-invasive prediction of oesophageal varices in patients with cirrhosis secondary to non-alcoholic fatty liver disease[J].2018,69(5).
[18]Wu Jian,Guo Naizhou,Zhang Xueyan,etc.HEV‐LF S S : A novel scoring model for patients with hepatitis E virus‐related liver failure[J].2019,26(11).
[19]Gui-Ping, Wen,Chang-Rong, Chen,Xiu-Yu, Song,etc.Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors.[J].2018,7(1).
[20]Gary, T.,Pichler, M.,Belaj, K.,etc.Lymphocyte-to-monocyte ratio: a novel marker for critical limb ischemia in PAOD patients[J].2014,68(12).