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Liver injury caused by antiviral agents for COVID-19

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Journal Title:
Chinese Journal of Clinical Infectious Diseases
Key Word:
新型冠状病毒;新型冠状病毒肺炎;抗病毒药物;肝损害;2019-nCoV;COVID-19;Antiviral agents;Liver damage

Abstract: Antiviral therapy is important for COVID-19. Currently, the anti-2019-nCoV drugs in clinical trials include broad-spectrum antiviral drugs (alpha interferon and ribavirin), hemagglutinin inhibitors (arbidol), human immunodeficiency virus protease inhibitors (lopinavir/ritonavir and darunavir/cobicistat), nucleoside analogues (favipiravir and remdesivir) and antimalarial drug (chloroquine); while liver damage may occur in some patients with the medication. This article reviews the research on liver damage associated with anti-2019-nCoV drugs, aiming at promoting the safe and effective antiviral therapy for COVID-19 patients.

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