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Types and epidemiological characteristics of influenza virus in Xi'an during 2009 to 2017

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Author:
No author available
Journal Title:
Chinese Journal of Clinical Infectious Diseases
Issue:
3
DOI:
10.3760/cma.j.issn.1674-2397.2018.03.005
Key Word:
流感病毒A型;流感病毒B型;流感监测;流行病学研究;Influenza A virus;Influenza B virus;Influenza surveillance;Epidemiologic studies

Abstract´╝Ü Objective To analyze the types and epidemiological characteristics of influenza virus in Xi'an during 2009 to 2017.Methods A total of 21 856 samples of throat swabs from patients with influenza like illness ( ILI) were collected from 5 national influenza sentinel surveillance hospitals from August 2009 to December 2017.Influenza virus nucleic acid was detected by real-time fluorescence quantitative PCR and virus types were confirmed , chick-embryo cells or Madin-Darby canine kidney (MDCK) cells were used to isolate influenza virus.SPSS 18.0 software was used for data analysis.Results The positive detection rate of influenza virus was 16.19%(3 539/21 856), the seasonal influenza A virus subtypes including H1, H3, the new type H1and H7 accounted for 62.39%(2 208/3 539), influenza B virus subtypes including Victoria , Yamagata and unclassified type B accounted for 37.50%( 1 327/3 539), and the mixed influenza virus infection accounted for 0.11%(4/3 539).The positive rate of influenza virus detected in different years was significantly different ( χ2=357.651, P <0.01).During January to March the major influenza A viruses accounted for 49.07%(947/1 930), influenza B viruses accounted for 50.93%(983/1 930); during October to December , the influenza A viruses accounted for 78.07%( 1 061/1 359 ), and influenza B viruses accounted for 21.93%( 298/1 359 ); there was significant difference in composition of type A virus and type B virus between different seasons ( χ2= 550.06, P<0.05).The positive detection rate of influenza virus in patients with ILI of age groups 0-3 years,>3-7 years,>7-13 years,>13-18 years,>18-24 years,>24-60 years and >60 years were 12.61%, 19.41%, 19.66%, 22.98%, 14.91%, 13.50% and 12.84%, respectively ( χ2=202.52, P<0.05).Conclusion Influenza A virus is common in Xi'an,winter and spring are the peak seasons for influenza epidemics.It is recommended for susceptible people to take influenza vaccination .

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