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Clinical and epidemiological characteristics of NDM-1 producing Enterobacteriaceae infection
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-2397.2018.01.010
- Key Word:
- 肠杆菌科;NDM-1;碳青霉烯酶;多位点序列分型;Enterobacteriaceae;NDM-1;Carbapenemas;Multilocus sequence typing
Abstract： NDM-1是一种新型的金属β-内酰胺酶,又称为新德里金属β-内酰胺酶-1.产NDM-1细菌常对包括碳青霉烯类在内的所有 β-内酰胺类抗生素耐药[1].自2008年Yong等[2]首次报道之后,blaNDM-1在世界范围内开始播散流行,给临床抗感染治疗带来极大挑战,对感染防控构成严重威胁.由于NDM-1具有严重耐药性和播散速度快的特点,已成为全球重点关注的问题.在中国,大多数已发现的产NDM-1菌株属于不同序列型(Sequence type, ST),呈散在分布.但Jin 等[3]报道山东省发现产NDM-1肺炎克雷伯菌的小范围暴发流行.因此,加强对这些菌株的监测,有助于临床抗感染治疗,有效的预防与控制这些菌株在医院感染的发生、流行和暴发.为了阐明携带NDM-1基因菌株临床感染特点及流行病学特征,本研究对分离自我院的17株携带NDM-1基因菌株感染患者的临床资料进行了回顾性分析,同时采用多位点序列分型(Multilocus sequence typing,MLST)技术对测试菌株进行了分型,报道如下.
- [1]曲俊彦,吕晓菊.碳青霉烯耐药肠杆菌科细菌感染治疗策略[J].2017,(4).
- [2]黄增光,夏淑,肖书念,等.产NDM-1肠杆菌科细菌的耐药机制和临床特征[J].2014,(5).
- [3]张雯,李传伟,刘刚,等.重症监护病房耐碳青霉烯肺炎克雷伯菌感染情况的临床分析[J].2017,(1).
- [4]A, Vatopoulos.High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece--a review of the current evidence.[J].2008,13(4).
- [5]Lee K,Yong D,Giske CG,etc.Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.[J].2009,53(12).
- [6]Rong Zhang,Lizhang Liu,Hongwei Zhou,etc.Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China[J].2017,19.
- [7]Hansen,L.H.,Johnson,T.J.,Hasman,H.,etc.Expansion of the IncX plasmid family for improved identification and typing of novel plasmids in drug-resistant Enterobacteriaceae[J].2012,68(1).
- [8]Qin,S.,Fu,Y.,Zhang,Q.,etc.High incidence and endemic spread of NDM-1-positive Enterobacteriaceae in Henan Province, China[J].2014,58(8).
- [9]Yan, Jin,Chunhong, Shao,Jian, Li,etc.Outbreak of multidrug resistant NDM-1-producing Klebsiella pneumoniae from a neonatal unit in Shandong Province, China.[J].2015,10(3).
- [10]Diancourt L,Passet V,Verhoef J,etc.Multilocus Sequence Typing of Klebsiella pneumoniae Nosocomial Isolates.[J].2005,43(8).
- [11]Wieler LH,Falush D,Maiden MCJ,etc.Sex and virulence in Escherichia coli: an evolutionary perspective[J].2006,60(5).
- [12]Georgios Meletis.Carbapenem resistance: overview of the problem and future perspectives.[J].2016,3(1).
- [13]Dallenne C,Da Costa A,Decre D,etc.Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae.[J].2010,65(3).