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Immune response of neutrophil against candida infection

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Author:
No author available
Journal Title:
Chinese Journal of Clinical Infectious Diseases
Issue:
5
DOI:
10.3760/cma.j.issn.1674-2397.2015.05.019
Key Word:
嗜中性粒细胞;念珠菌属;免疫;嗜中性粒细胞胞外诱捕网;Neutrophil;Candida;Immunity;Neutrophil extracellular traps

Abstract: Neutrophil ( PMN) is the main immune effect cell of killing candida yeast cells .It can recognize different cellular components of candida through a variety of surface and intracellular pattern recognition receptors , phagocytose and/or form extracellular traps to capture candida yeast and mycelia , then kill them with oxidation or non-oxidation mechanism .It can also adjust innate immunity and adaptive immune response in candida infection by interaction with other immune cells .This article reviews recent progress of the multiple subsets of neutrophil , the mechanism of its recognizing and killing candida , and the interaction with other immune cells , to provide new perspectives for clinical therapy of candida infections .

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