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Research progress on correlations between interlukin-28B polymorphism and hepatitis B
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-2397.2015.01.020
- Key Word:
- 肝炎,乙型,慢性;白介素-28B;基因多态性;干扰素类;Hepatitis B,chronic;Interlukin-28B;Gene polymorphism;Interferons
Abstract： Interferon (IFN) is one of the commonly used anti-HBV drug in clinic,in which IFN-λ is a new type of IFN,including IFN-λ1,IFN-λ2 and IFN-λ3 (also called IL-29,IL-28A and IL-28B,respectively).Researches in recent years show that IFN-λ3 (IL-28B) polymorphism seems to be involved in the onset of hepatitis B,the response to antiviral therapy and the outcome of HBV infection.This paper reviews the correlations between IL-28B polymorphism and the spontaneous clearance of HBV,the progression of HBV infection,the occurrence of liver cancer and the therapeutic effect of IFN treatment.
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