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Detection of plasma presepsin for diagnosis of hospital-acquired pneumonia in postoperative patients with cerebral hemorrhage

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Author:: No author available

Journal Title:: Chinese Journal of Clinical Infectious Diseases

Issue:: 1

DOI:: 10.3760/cma.j.issn.1674-2397.2015.01.016

Key Word:: 脓毒症;肺炎,细菌性;可溶性CD14亚型;Sepsis;Pneumonia,bacterial;Solube CD14 subtype

Abstract：脑出血是重症监护病房(ICU)常见的急危重症,由于患者多为中老年且伴意识障碍,术中及术后需气管插管呼吸机支持,容易并发医院获得性肺炎(Hospital acquired pneumonia,HAP)而导致病情恶化或死亡.神经外科ICU医院获得性肺部感染的发生率为10％～ 30.9％[1-3].尽管痰培养能获得较早的临床资料,但耗时较长,影响治疗决策和预后.因此,探寻感染诊断的敏感指标显得尤为重要.Presepsin(可溶性CD14片段,sCD14-ST)是近年发现的脓毒血症早期诊断的敏感指标[4-6].本研究通过检测84例脑出血术后患者血浆Presepsin水平,结合临床资料及降钙素原(Procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)及白细胞(White blood cell,WBC)水平,探讨其在脑出血术后医院获得性肺炎中的临床意义.

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