You Position: Home > Paper
Ebola virus disease：current knowledge and future directions for study
( views:345, downloads:84 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-2397.2014.06.001
- Key Word:
- 埃博拉出血热;翼手目;疾病传播;ZMapp;伦理学,医学;Hemorrhagic fever,Ebola;Chiroptera;Disease transmission;ZMapp;Ethics,medical
Abstract： 埃博拉病毒病（ Ebola virus disease）是一种急性出血性传染病，主要通过接触传播，临床表现为突起发热、肌肉酸痛、腹泻、出血和多脏器损害，伴随外周血白细胞、血小板计数降低等。埃博拉病毒是人类历史上最致命的病毒之一，人感染后病死率在50％～90％，被世界卫生组织（ WHO）列为生物安全第四级（ Biosafety level 4， BSL-4）病毒，同时也被视为生物恐怖工具之一。
- [1]Kevin J, Olival,David T S, Hayman.Filoviruses in bats: current knowledge and future directions.[J].2014,6(4).
- [2]Xu, Wei,Edwards, Megan R.,Borek, Dominika M.,etc.Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1[J].2014,16(2).
- [3]Nabel EG,Yang ZY,Sanchez A,etc.Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury.[J].2000,6(8).
- [4]Jordan, Levinson,Tiffany L, Bogich,Kevin J, Olival,etc.Targeting surveillance for zoonotic virus discovery.[J].2013,19(5).
- [5]Nadia, Wauquier,Pierre, Becquart,Cindy, Padilla,etc.Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis.[J].2010,4(10).
- [6]Feldmann H,Geisbert TW.Ebola haemorrhagic fever.[J].2011,377(9768).
- [7]Basler CF.,Mikulasova A.,Martinez-Sobrido L.,etc.The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3[J].2003,77(14).
- [8]Jose M Martin-Moreno,Gilberto Llinas,Juan Martinez Hernez.Is respiratory protection appropriate in the Ebola response?[J].2014,384(9946).
- [9]Nabel, GJ,Graham, BS,Sullivan, NJ,etc.Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule[J].2009,7(5).
- [10]J. LEGRAND,A. J. VALLERON,A. FLAHAULT,etc.Understanding the dynamics of Ebola epidemics[J].2007,135(4).
- [11]Kevin J, Olival,Ariful, Islam,Meng, Yu,etc.Ebola virus antibodies in fruit bats, bangladesh.[J].2013,19(2).
- [12]David T S, Hayman,Meng, Yu,Gary, Crameri,etc.Ebola virus antibodies in fruit bats, Ghana, West Africa.[J].2012,18(7).
- [13]Roger W. Barrette,Samia A. Metwally,Jessica M. Rowland,etc.Discovery of Swine as a Host for the Reston ebolavirus[J].2009,325(Jul.10 TN.5937).
- [14]Basler CF,Reid SP,Martinez O,etc.Ebola virus VP24 binds karyopherin alpha 1 and blocks STAT1 nuclear accumulation[J].2006,80(11).
- [15]Sanchez A,Lukwiya M,Bausch D,etc.Analysis of human peripheral blood samples from fatal and nonfatal cases of ebola (Sudan) hemorrhagic Fever: cellular responses, virus load, and nitric oxide levels.[J].2004,78(19).
- [16]Margaret Chan.Ebola Virus Disease in West Africa - No Early End to the Outbreak[J].2014,371(13).
- [17]Davis KJ,Hensley LE,Kagan E,etc.Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event.[J].2003,188(11).
- [18]Hana M, Weingartl,Carissa, Embury-Hyatt,Charles, Nfon,etc.Transmission of Ebola virus from pigs to non-human primates.[J].2012,2.