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New strategies on antiviral treatment of chronic hepatitis B
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-2397.2014.04.002
- Key Word:
- 肝炎,乙型,慢性;抗病毒药;免疫调节;Hepatitis B,chronic;Antiviral agent;Immunomodulation
Abstract： 慢性乙型肝炎(CHB)是一种免疫缺陷性疾病.近10多年来,抗病毒治疗取得了很大的进展.当今,抗病毒治疗药物有二大类,即核苷(酸)类(NAs)和干扰素类.已上市的NAs有拉米夫定(LAM)、阿德福韦(ADV)、替比夫定(LDT)、恩替卡韦(ETV)以及替诺福韦(TDF);干扰素有普通干扰素(IFN)和聚乙二醇干扰素(PegIFN)-α.TDF、ETV等NAs具有很强的抑制HBV DNA作用,长期治疗可使90％以上的CHB患者实现HBV DNA低载量,并可改善肝组织炎症坏死和纤维化,减少肝衰竭和肝细胞癌(HCC)的发生,降低病死率[1-3].
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