Abstract： Objective To investigate the expression of platelet membrane glycoproteins in patients infected with severe fever with thrombocytopenia syndrome virus (SFTSV).Methods Twenty-eight SFTSV infected patients,including 8 cases with multiple organ dysfunction syndrome (MODS) and 20 without MODS,were collected from Zhoushan Hospital during May 2011 and May 2013.Platelet routine test and the detection of the positive rates and mean fluorescence intensity (MFI) of platelet membrane glycoproteins (CD41a,CD42a,CD61,CD62p) were performed before and after adenosine diphosphate (ADP)-induced activation treatment.Independent-samples t test was used to compare the results between two groups.Results Compared with non-MODS group,the platelet count had no difference in MODS group (t =0.139,P ＞0.05),but the mean platelet volume was larger (t =6.417,P ＜0.01),and the platelet distribution width was wider (t =9.664,P ＜ 0.01).The positive expression rate and MFIs of membrane glycoproteins were higher in MODS group than those in non-MODS(CD41a:t =14.486 and 49.419,P ＜ 0.01 ; CD42a:t =41.693 and 58.160,P ＜ 0.01 ;CD61:t =15.452 and 19.251,P ＜ 0.01 ; CD62p:t =18.230 and 24.258,P ＜ 0.05).After ADP-induced activation treatment,the positive expression rate and MFI did not significantly changed in MODS group (CD41a:t =1.364 and 1.237,P ＞ 0.05 ; CD42a:t =1.247 and 1.448,P＞0.05; CD61:t =1.258 and 1.354,P＞0.05; CD62p:t =1.213 and 1.147,P＞0.05),while there were significant changes in non-MODS group (CD41a:t =15.891 and 18.417,P ＜ 0.01 ;CD42a:t =54.367 and 14.217,P＜0.01; CD61:t =16.257 and 21.348,P＜0.01; CD62p:t =58.268 and 18.145,P ＜ 0.01).Conclusions Platelet glycoprotein expression and MFI in SFTSV infected patients with MODS are higher than those without MODS,and the sustained activation expression ability is extremely low in patients with MODS.Detection of platelet membrane glycoprotein may be used to evaluate the disease severity for patients infected with SFTSV.