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Human infection with Middle East respiratory syndrome coronavirus
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-2397.2013.04.002
- Key Word:
- 冠状病毒科;中东呼吸综合征冠状病毒;感染;Coronaviridae;Middle East respiratory syndrome coronavirus;Infection
Abstract： 中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)是一种新型冠状病毒,于2012年6月由病毒学家Zaki AM 从沙特阿拉伯Jeddah市一例60岁急性肺炎伴肾功能衰竭患者的呼吸道上皮细胞中分离到并首次报道,暂称HCoV-EMC[1].世界疫症情报网(ProMed-mail)将其排在第6种新型人类冠状病毒列表中,俗称"沙特SARS病毒".该病毒自2012年在沙特阿拉伯发现并感染人类后,迅速传播至约旦、卡塔尔、阿联酋、突尼斯等中东地区,在曾去中东旅行的欧洲(法、英、德、意)游客中也发现确诊患者.人感染该病毒后病死率极高,医学界已高度重视.2013年5月28日WHO宣布接受国际病毒分类委员会冠状病毒研究小组建议,将此型病毒命名为"中东呼吸综合征冠状病毒(MERS-CoV)".本文将此病毒特性及对人类致病的主要概况总结如下,供参考.
- [1]R G, Pebody,M A, Chand,H L, Thomas,etc.The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012.[J].2012,17.
- [2]Guberina,H.,Hartmann,W.,Seilmaier,M.,etc.Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection[J].2013,13(9).
- [3]Ali Moh Zaki,Theo M. Bestebroer,Ser van Boheemen.Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia[J].2012,367(19).
- [4]Guery,B.,Poissy,J.,ElMansouf,L.,etc.Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: A report of nosocomial transmission[J].2013,381(9885).
- [5]Raoul J. de Groot,Susan C. Baker,Ralph S. Baric,etc.Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group[J].2013,87(14).
- [6]V. Stalin Raj,Huihui Mou,Saskia L. Smits,etc.Dipeptidyl peptidase 4 is a functional receptor for theemerging human coronavirus-EMC[J].2013,495(Mar.14 TN.7440).
- [7]Nianshuang Wang,Xuanling Shi,Liwei Jiang,etc.Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4[J].2013,(8).