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Serum IL-32 changes and its clinical significance in hepatitis B patients with liver failure
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Clinical Infectious Diseases
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-2397.2013.03.012
- Key Word:
- 肝炎病毒,乙型;肝硬化;肝功能衰竭;白细胞介素-32;Hepatitis B virus;Liver cirrhosis;Liver failure;Interleukin-32
Abstract： 我国是乙型肝炎病毒(HBV)感染率较高的国家,随着疫苗接种等预防措施的实施,感染人数较之前明显减少,但1 ～59岁的普通人群HBsAg阳性率仍有7.18％[1].迄今,HBV引起肝损伤,尤其是引起肝衰竭的确切免疫机制还未完全阐明.白细胞介素(IL)-32是Kim等[2]利用基因芯片技术研究IL-18诱导高表达基因时意外合成的,具有促进炎症反应的作用,但其在HBV引起肝衰竭中的作用鲜见报道.本研究旨在通过检测HBV相关肝衰竭患者的血清IL-32表达水平,探讨其在肝衰竭中的重要意义.
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