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Plasma levels of IFNγ, IL-10 and IL-18 and their relationships with liver function and HBV DNA load in chronic hepatitis B patients receiving adefovir dipivoxil

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
Issue:
1
DOI:
10.3760/cma.j.issn.1674-2397.2011.01.009
Key Word:
肝炎,乙型,慢性;阿德福韦酯;干扰素γ;白细胞介素10;白细胞介素1β;Chronic hepatitis B;Adefovir dipivoxil;Interferon γ;Interleukin-10;Interleukin-1β

Abstract´╝Ü @@ 慢性乙型肝炎(CHB)的发病机制至今尚不完全清楚,免疫相关细胞因子在乙型肝炎病毒(HBV)感染及其慢性化过程中的作用越来越被人们所重视,尤其是Th1和Th2型细胞因子的变化,可直接导致Th1/Th2免疫平衡发生偏离,进而导致HBV感染慢性化[1].阿德福韦酯是新一代抗HBV药物,在抑制HBV复制的同时,可明显改善CHB患者的肝脏组织学表现及血清丙氨酸转氨酶(ALT)和HBeAg等指标[2].

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