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Continuous blood purification for immune and inflammatory response in patients with severe sepsis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1674-2397.2010.06.012
- Key Word:
- 脓毒症;连续血液净化;免疫;炎性反应;急性生理与慢性健康评估Ⅱ;Sepsis;Continuous blood purification;Immunity;Inflammation;Acute physiology and chronic health evaluation Ⅱ
Abstract： @@ 严重脓毒症及其相关的脓毒性休克和多脏器功能障碍综合征是危重病患者死亡的主要原因之一[1].传统的观点认为,脓毒症是一种过度的炎性反应,但应用针对某种炎性介质的抗炎治疗没有在临床获得预期效果[2-4].后期研究又发现,脓毒症免疫功能紊乱中更多的是由于"过度免疫抑制"的参与[5].应用连续血液净化治疗(continuous blood purification,CBP)清除血液中过多的炎性细胞因子是近年来研究较多的治疗手段,但其是否能真正有效地改善患者的炎性状态及其与临床治疗作用的关系,仍存在较多争议[6-7].本试验旨在研究严重脓毒症患者全身炎性反应和免疫抑制是否同时存在,以及应用CBP能否纠正患者免疫炎性反应紊乱并改善临床预后.
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