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Research progress of CD127 expression on T lymphocytes in peripheral blood with HIV infection
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1674-2397.2010.04.021
- Key Word:
- 白细胞介素7受体α亚单位;T淋巴细胞;HIV感染;Interleukin-7 receptor alpha submit;T lymphocyte;HIV infection
Abstract： @@ 白细胞介素7受体(IL-7R)是由α链及γ链构成的,γ链受体广泛表达于淋巴细胞,是IL-2、IL-4、IL-9、IL-15和IL-21的通用受体,可以与这些细胞因子结合并相互作用.CD127是IL-7Rα链,在T淋巴细胞发育过程中,胸腺细胞的分化依赖于IL-7的表达.IL-7可以通过CD127刺激外周非同种异基因反应性T淋巴细胞的增殖,并通过抗凋亡作用促进T淋巴细胞的存活与重构,维持T淋巴细胞内环境稳态[1].
- [1]叶军,陈亚宝,徐洪涛,等.乙型肝炎病毒感染者外周血T淋巴细胞CD127的表达及其意义[J].2009,(12).
- [2]Crawley AM,Angel JB,Gee K,etc.IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells.[J].2007,19(12).
- [3]Sieg SF,Bazdar DA,Kalinowska M.Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging.[J].2009,199(7).
- [4]Harari A,Enders FB,Cellerai C,etc.Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure[J].2009,83(7).
- [5]Sasson SC,Rosenberg ES,Koelsch K,etc.Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.[J].2006,80(20).
- [6]Faller E,Kakal J,Kumar R,etc.IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.[J].2009,21(3).
- [7]Zaunders JJ,Kelleher AD,King EM,etc.Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.[J].2006,193(4).
- [8]Harbertson J,McBreen ME,Kondrack RM,etc.Interleukin 7 regulates the survival and generation of memory CD4 cells.[J].2003,198(12).
- [9]Kiazyk SA,Fowke KR.Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection[J].2008,16(12).
- [10]Matu L,Embree JE,Kimani J,etc.IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.[J].2006,36(2).
- [11]McVey MJ,Faller EM,Kakal JA,etc.Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein.[J].2006,43(3).
- [12]Altman JD,Montroni M,Feinberg MB,etc.Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals.[J].2005,174(5).
- [13]Boettler T,Bengsch B,Spangenberg HC,etc.Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection[J].2006,80(7).
- [14]Eng JM,Greenberg AS,Van Den Brink MR,etc.IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation.[J].2003,112(7).
- [15]Draenert R,Woodberry T,Addo M,etc.HIV-specific CD8 T cells express low levels of IL-7R alpha: Implications for HIV-specific T cell memory[J].2006,353(2).