You Position: Home > Paper
Management of fungal infections in patients with liver transplantations
( views:274, downloads:56 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-2397.2009.01.001 10.3760/cma.j.issn.1674-2397.2009.01.001
- Key Word:
- 肝移植;真菌;侵袭性真菌感染;Liver transplantation;Fungus;Invasive fungal infection
Abstract： @@ 侵袭性真菌感染(invasive fungal infection,IFI)的发生近年在肝移植受者中呈上升趋势,发生率在5%～42%[1-5],多发生于移植术后3个月内,也有患者在术后3个月至1年内发生.随着活体肝移植的广泛开展,急诊肝移植成为众多危重患者的选择,大大提高了肝移植术后IFI的发牛率.国内外各移植中心报道肝移植术后IFI造成的病死率为10%～80%,大部分报道的数据高于50%[3-4],认为IFI是肝移植受者死亡的重要原因之一.IFI对肝移植受者预后的影响日益受到关注,如何对其进行积极预防和有效治疗是临床医师面临的新的挑战.
- [1]郑树森,吴健,梁廷波,等.肝移植与感染（附52例肝移植分析）[J].2002,(2).
- [2]Paul A,Saner FH,Broelsch CE,etc.Pulmonary and blood stream infections in adult living donor and cadaveric liver transplant patients.[J].2008,85(11).
- [3]Saner F,Paul A,Rath P,etc.Safety profile of concomitant use of caspofungin and cyclosporine or tacrolimus in liver transplant patients.[J].2006,34(6).
- [4]Alejandro Sanchez,Robert Larsen.Fungal infections in solid organ transplantation[J].2008,12(6).
- [5]Kusne S,Husain S,Wagener MM,etc.Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study.[J].2003,75(12).
- [6]Herbrecht R,Denning DW,Patterson TF,etc.Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.[J].2002,347(6).
- [7]Singh Nina,Wagener MarilynM,Marino IgnazioR,etc.Trends in invasive fungal infections in liver transplant recipients: correlation with evolution in transplantation practices.[J].2002,73(1).
- [8]Houston S,Klintmalm GB,Fisher RA,etc.Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter, observational study.[J].2006,81(3).
- [9]Alexander BD,Perfect JR,Daly JS,etc.Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant.[J].2008,86(6).